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KMID : 0388220130200030198
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Journal of the Korean Rheumatism Association
2013 Volume.20 No. 3 p.198 ~ p.201
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A Case of Skin Sclerosis Associated with Docetaxel Chemotherapy for Non-Small Cell Lung Cancer
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Nam Jae-Hyung
Moon Jong-Joo
Lee June-Hyuk
Park Sung-Woo
Jang An-Soo
Kim Do-Jin
Jeon Chan-Hong
Koh Eun-Seok
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Abstract
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A 64-year-old woman was diagnosed with non-small cell lung cancer. Her disease was stage 4 (T2N2M1) with squamous cell carcinoma. She had been treated with docetaxel and carboplatin. After a completion of 11 cycle of chemotherapy, edema appeared on both feet and had spread rapidly up to the pretibial area without response to diuretics. Sclerotic changes and pigmentation followed but both knees and other parts of the body were spared. There was no evidence of vascular occlusions. On serologic tests, antinuclear, anti-centromere, and anti-topoisomerase I antibodies were all negative. A skin biopsy revealed diffuse infiltration of lymphocytes and discretely thickened collagen bundles in the superficial dermis. After discontinuing docetaxel chemotherapy, she was treated with prednisolone and D-penicillamine and sclerotic changes on the lower legs were improved.
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KEYWORD
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Docetaxel, Scleroderma, Lung cancer, Adverse effect
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